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2) Acid-sensitive cleavable linkers: Mylotarg, Besponsa, Trodelvy The acid-sensitive strategy is to use a lower pH of the endosome (pH = 5-6) and lysosome (pH = 4.8) compartments compared to the cytoplasm (pH = 7.4) to trigger the hydrolysis of an acid-labile group within the linker, such as a hydrazone

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Enhanced follicular development and normalized estrous cycles have been reported in obese rodent models

Notably, ammonia is simultaneously generated as a byproduct of glutamine deamination