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Because it inhibits oxidative stress on the cochlea and reverses its effects through autoprotective activity, zingiberene may protect rats from the ototoxic effects of Paclitaxel (Dincer et al

This shift toward MC4R selectivity makes PT141 a useful tool for isolating MC4Rmediated signalling including Gproteincoupled cAMP and phospholipaseC cascades, intracellular calcium flux, and ERK/MAPK pathway activation within neuronal and receptorexpressing model systems

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