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[ 12 ] Melatonin is one of the body's primary circadian signals, doing more than simply promoting sleep

It is not approved by the FDA for any medical application and is not intended for human or veterinary use

19 Although the mechanisms underlying endothelial dysfunction are multifactorial, a growing body of evidence suggests that increased ROS production contributes considerably to this phenomenon in several ways

The complete chemical structure of the molecule was determined by Dorothy Hodgkin based on crystallographic data and published in 1955 [147] and 1956, [148] for which, and for other crystallographic analyses, she was awarded the Nobel Prize in Chemistry in 1964

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