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In a single piece, he concisely captures: the state of the field the most important clinical trials where the pipeline is headed These Clinical trials are raising the bar and expanding future treatment options: Retatrutide ~24% weight loss (triple agonist) MariTide 1216% weight loss (GLP-1 + GIP antagonist) CagriSema up to 20% weight loss + ~2% HbA1c drop Orforglipron oral GLP-1, HbA1c 1.5%, weight 7.6% IcoSema weekly semaglutide + once-weekly insulin Even more exciting
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GLP-1,/, BBX BBX L- 50% L-L- -L-CoQ10CLA -L-CoQ10CLA ATP ATP 50% CLA BBX BBX 112 11 30 12 30 BBX 1130 1302 BBX: 20,00022,000 GLP-1BMI 20 2 GLP-1 2 13 GLP-1 GLP-1 GLP-1 GLP-1 30 1 1 7mg 113mg4117mg + 330 30 7 30 30 18 mg 90009900 mg 1800019800 2,200 1 2GIPGLP-1 1 1 2.5mg4 5mg 72 72 1 2,200 L - 70007,700 300L2000
If it becomes apparent that this is an ongoing, relapsing, recurring problem and people are just going to lose the plot because they arent getting the change, then absolutely, lets have the conversation [about semaglutide]
A new GLP-1 oral tablet has shown promising results in a phase 2b clinical trial for the treatment of type 2 diabetes
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