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It aligns with the clinical consensus that meaningful weight loss outcomes with GLP-1 medications require at least 812 weeks of consistent treatment at therapeutic doses

Diabetes Care 39 , 222230 (2016) L.A

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The relative contribution of each system is different depending on the cell type, as discussed in the following section

28 Moreover, research involving more diverse Japanese populations, beyond the trial informed cohorts used in the present analysis, will be important to ensure generalizability across demographic and clinical characteristics

In adults with type 2 diabetes, doses up to 12 mg weekly produced roughly 17% weight loss at 36 weeks alongside ~2.0% HbA1c reductions versus placebo [3]