IM B12 injection is especially appropriate when oral supplementation has been inadequate, when absorption is compromised, or when neurological symptoms are present (Stabler, New England Journal of Medicine , 2013)
What they do not have is a body of controlled evidence showing that injecting them causes clinically significant weight loss independent of diet, exercise, and the rest of a supervised program
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Diagnosing vitamin B12 deficiency requires professional medical assessment, not just self-evaluation of symptoms
No long-term safety or efficacy data exists
[5] [10] In 2023, it was the 104th most commonly prescribed medication in the United States, with more than 6 million prescriptions