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Research suggests that people who are at a higher weight show reduction in GLP-1 signalling

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Dohi DE, H-Y L, Han GR, Walsh GL, Nesbitt JC, Andreeff M , Hong WK, Kurie JM

MGF and Cardiac Function Cross-Species Validation Delivery of the MGF E-domain peptide via peptide-eluting polymeric microstructures to post-MI mice decreased mortality, ameliorated the decline in haemodynamics, and delayed cardiac decompensation with the beneficial cardiovascular effects of the stabilised E-domain peptide confirmed across rodent and large animal models, providing a platform for understanding local tissue IGF-1 autocrine/paracrine modulation in cardiac repair research