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We conducted a target trial emulation using TriNetX electronic health records (20152024)

Retatrutide is a novel synthetic peptide that acts as a triple receptor agonist targeting GIP (glucose-dependent insulinotropic polypeptide) , GLP-1 (glucagon-like peptide-1) , and glucagon receptors

That means the vast majority of weight lost, approximately 77%, was fat

GIP(3-30)NH2 is an efficacious GIP receptor antagonist in humans: a randomised, double-blinded, placebo-controlled, crossover study