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Binding of the ligand (GLP-1) or its analog on the extracellular side of the protein induces conformational changes that are sensed by the G-proteins on the cytoplasmic face - initiating a signaling cascade (see Figure 3 a and b)
Epigenetic transgenerational actions of endocrine disruptors
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Despite the potential for drug abuse or tolerance using stimulants, patients with narcolepsy rarely exhibit addiction to their medication
However, during hyperglycemia, cotadutide, liraglutide, and vehicle control groups responded with normal increases of insulin secretion, while g1437-treated mice were unable to mount an insulin secretory response
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