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Animal studies have shown that a combination of exercise and dietary modification results in an alteration of the intestinal microbiota, an increase in the production of intestinal mucins, and a reduction of endotoxin and inflammatory cytokine production, which in turn prevents the development of steatosis (74, 143, 282285)
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Interaction terms between treatment and key baseline factors (e.g., baseline epigenetic age acceleration or baseline BMI) were explored to see if the treatment effect varied by these factors
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