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GLP-1-derived peptides (liraglutide, exendin-4, and exendin 939) effectively inhibited capsaicin (CAP)-induced currents and calcium responses in cultured sensory neurons and TRPV1-expressing cell lines

J., & Bartlett, S

Brain Nerve 2007;59(10):1141-47 10

Another group was screening for ligands that activated orphan G-protein coupled receptors (GPCRs) that would induce transient calcium currents in cells expressing the orphan GPCRs

They result from the release of histamine and other inflammatory mediators from mast cells in the skin

Always consult your physician or a qualified healthcare provider before starting, stopping, or modifying any medication or exercise program.