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Her limb volume difference spiked to 10.3% and her LLIS demonstrated severe disability with an impairment score that nearly tripled to 52.9

The ideal characteristics of translational safety biomarkers of organ injury are that they provide more sensitive and specific information than current clinical chemistry biomarkers, can be detected through robust analytical assays in relevant translational species (rat, dog, mouse or monkey) and in humans, can be measured noninvasively or in accessible fluids like blood or urine, can predict or monitor severity of histopathology in nonclinical species, are specific for organ injury or mechanisms of toxicity that lead to organ injury, are specific to tissue location and are insensitive to nontoxic perturbations (exercise, diet, age, and other diseases and toxicities to other organs) (Amacher 2010

Effects of L-carnitine supplementation on markers of exercise-induced muscle damage in healthy adults: A systematic review and meta-analysis of randomized controlled trials