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JM volunteers that his brother recently died following a myocardial infarction and he is eager to implement changes to minimize his risk of a cardiovascular event following his revascularization procedure in early 2019
Nevertheless, multiple degradation-resistant and structurally distinct GLP-1RAs do not generate the same GLP-1 metabolites yet reduce blood pressure, increase heart rate, inhibit enterocyte chylomicron secretion and reduce the extent of myocardial infarction in rats and mice through mechanisms requiring the canonical GLP-1R [99, 105,106,107,108]
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