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doi:10.17179/excli2020-2487Google ScholarPubMed Hellings, JA, Reed, G, Cain, SE, et al
Reasons to track liver enzymes while on GLP-1s: Rapid fat mobilization during weight loss can temporarily affect liver function Pre-existing fatty liver may improve, and testing confirms progress Dehydration from reduced appetite can concentrate liver enzymes Combining GLP-1s with other medications increases liver processing demands Some individuals experience transient enzyme elevations that resolve with time If you're already monitoring pancreatic enzymes like amylase and lipase on GLP-1 therapy, adding liver markers gives you a complete picture of how your body is responding
A patient with significant metabolic dysfunction might benefit from standard-dose semaglutide or tirzepatide's stronger appetite suppression
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Through its dual insulinotropic and glucagonotropic effects on stabilizing glucose levels, GIP could provide a buffer against hyperglycemia when large amounts of glucose are consumed and mitigate reactive hypoglycemia, especially after meals with high fat content
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