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In conclusion, the present results suggest new and unexpected links between fatigue, peripheral 5-HT, and L-carnitine in CFS and hypothyroidism, and offer testable hypotheses for future mechanistic and clinical studies
Exenatide was the worlds first clinically used GLP-1RA, developed in 1995 and approved for the treatment of type 2 diabetes mellitus (T2DM) in 2005 due to its proven ability to regulate postprandial glucose levels effectively (Furman, 2012)
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GLP-1R, when activated, initiates downstream signaling effects that lead to an overall decrease in blood glucose levels, including potentiation of insulin secretion, reduced glucagon secretion, and weight loss via satiety induction that results in increased insulin sensitivity (2)
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