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As an emerging clinical model, PDOs hold great promise not only for elucidating resistance mechanisms but also for drug screening and guiding individualized therapeutic strategies

Nanomedicine is exploring GHK-Cu as a component of functionalized nanoparticles for targeted drug delivery

Biochemistry 35 , 44454456, doi: 10.1021/bi9521093 (1996)

These typically resolve with continued use or dose adjustment

In human monocytes/macrophages, the amino acid transporter SLC7A5 has been shown to participate in immunometabolic reprogramming and to influence the intensity of inflammatory responses, suggesting that differences in transporter expression may be one of the key factors underlying tissue specificity and interindividual heterogeneity ( In addition, one-carbon metabolism and redox homeostasis also constitute important regulatory layers of macrophage polarization