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View course detailsSave automatically with 2+ courses Learn vitamin C injection theory - immune and skin benefits, dosing awareness and safe delivery

[95] Intramuscular or intravenous injection [edit] Injection of hydroxycobalamin is often used if digestive absorption is impaired, [2] but this course of action may not be necessary with high-dose oral supplements (such as 0.51.0 mg or more), [97] [98] because with large quantities of the vitamin taken orally, even the 1% to 5% of free crystalline B 12 that is absorbed along the entire intestine by passive diffusion may be sufficient to provide a necessary amount

However, the histamine response can become a disruptive force if it is not properly regulated

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Local injection may provide higher concentration at the target site

Only a handful of small studies exist, and the largest of them was never even published