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Furthermore, MDA can directly interact with DNA, causing strand breaks and base modifications, thereby adversely affecting sperm DNA integrity and reducing fertilization potential (115, 116)

The copper(II) ion in GHK-Cu is a cofactor for lysyl oxidase (LOX), the enzyme responsible for collagen and elastin cross-linking in blood vessel walls

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Fibrillar structures were also observed, but they were not associated with copper ions, suggesting that copper promotes the formation of toxic oligomers that disrupt membranes ( Impaired autophagy plays an important role in IAPP toxicity, due to the accumulation of excessive amounts of IAPP oligomers intracellularly

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