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This evidence for lesion heterogeneity is important, as it emphasizes that different lesions may require different treatment strategies to enhance remyelination in some, promoting differentiation may suffice, whereas in others, increasing aOPC numbers will be required
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The absence of a regulated dose is a significant limitation and places substantial responsibility on individuals who choose to use this compound to research, understand pharmacology, and make informed decisions about whether to use it at all
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The single published human case series and unpublished clinical trial data provide preliminary safety reassurance but insufficient evidence for clinical efficacy claims
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