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Left panel (Mechanism of Action & Pharmacodynamics) : Imipramine inhibits the serotonin transporter (SERT) and norepinephrine transporter (NET), resulting in increased synaptic concentrations of serotonin and norepinephrine (dual monoamine reuptake inhibition)
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MC1R activation can also promote macrophage cholesterol efflux via ABCA1/ABCG1 and confer neuroprotective effects through cAMP/PKA/Nurr1 signaling, illustrating broader antiinflammatory and tissueprotective roles beyond pigmentation
These experiments were conducted in triplicate
Regulatory developments in this space are ongoing
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