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References: Mutation of the mouse klotho gene leads to a syndrome resembling ageing Kuro-o et al
Its best-characterized action is at MC1R on melanocytes, where receptor activation raises intracellular cyclic AMP and upregulates tyrosinase, the rate-limiting enzyme of melanin synthesis, in reported research this drives increased eumelanin production and skin darkening
Lipids 48 , 319332, doi: 10.1007/s11745-013-3774-6 (2013)
GLP-1 medications can also cause tiredness, especially when treatment starts or doses increase, because of reduced calorie intake, dehydration, gastrointestinal side effects, and changes in glucose levels
If you have any questions about side effects or how to manage them, to support you
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