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The feedback inhibition of IGF-1 on further GH secretion stayed intact, preventing the GH excess that drives insulin resistance with direct injection
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Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase beta-cell mass in fetal sheep
The brain is vulnerable to oxidative stress because of its high demand for oxygen, abundant fatty acids that are targets of lipid peroxidation, and lower antioxidant enzyme activities compared to other organs
Validating these findings, we show that deletion of the mitochondrial pyruvate carrier, which is known to decrease TCA cycle activity and protect the liver from diet-induced injury, also diminished NADPH, elevated glutathione oxidation, and alleviated ER stress
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