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In vivo studies, such as that by Morris et al., used a preclinical model of a high-fat diet in infant rats to mimic insulin resistance, identifying impaired nigrostriatal dopamine function as a consequencea hallmark of PD neuropathology [152]

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The inhibitory actions of long-acting GLP-1RAs on gastric emptying in people with type 2 diabetes or obesity is more variable, with substantial tachyphylaxis evident in some [76], but not all [77], studies

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They relieved the thermal and mechanical nociceptive response of OXA-induced painful neuropathy using the tail immersion test in cold water (10C) and the von Frey test (Azevedo et al., 2013)