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SITAGLIPTIN PHOSPHATE + METFORMIN HCl (JANUMET) is indicated as part of triple combination therapy with a sulfonylurea as an adjunct to diet and exercise in patients with type 2 diabetes mellitus inadequately controlled with any two of the three agents: Metformin, sitagliptin, or a sulfonylurea
Intriguingly, differential expression of A3AR in intracellular compartments was observed in the liver tissue of healthy controls and NAFLD patients
Another trial, centered around 405 patients, should conclude in December 2025
A 2024 EMA review concluded there is no causal association between GLP-1 receptor agonists and suicidal thoughts or self-harm
Across the major GLP-1 trials, ~2545% of the weight lost is lean tissue: muscle and bone, the organs that keep you independent at 75
This has the additional advantage of reducing body weight by reducing percentage fat in the body
