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[10] [11] Whilst semaglutide's primary actions target glucose regulation through enhanced insulin secretion, reduced glucagon, and slowed gastric emptying, changes in autonomic function could theoretically affect thermoregulation and vascular tone, though this remains speculative

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However, expression levels of some genes were altered by semaglutide or tirzepatide in non-diabetic models

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Cav-1 is crucial in maintaining vascular health but a paradoxical role of Cav-1 in cardiovascular pathophysiology has also been reported 19,38

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