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Its anti-inflammatory mechanisms include reducing TNF-alpha production, downregulating NF-kB activation, and decreasing oxidative stress through enhanced antioxidant enzyme activity
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Klopp AH, Lacerda L, Gupta A, Debeb BG, Solley T, Li L, Spaeth E, Xu W, Zhang X, Lewis MT, Reuben JM, Krishnamurthy S, Ferrari M, Gaspar R, Buchholz TA, Cristofanilli M, Marini F, Andreeff M , Woodward WA
The empiric use of naloxone in patients with altered mental status: a reappraisal
However, it is important to describe this as modulation of signaling pathways, not as proven therapeutic effects
DiNicolantonio, C.J
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