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For women, perimenopause and menopause often lead to lower estrogen and progesterone, while men experience andropause, a gradual decrease in testosterone
The list goes on and on, but those are just the more common symptoms
Oxidation of the solvent-exposed W32 residue in SOD1 in particular has been associated with aggregation of mutant SOD1 in vitro and in vivo (Taylor et al., 2007
Fourteen genes whose expression is significantly correlated with regional emphysema severity or transcription factors that are highly connected to these genes in the relevance network were selected for quantitative RT-PCR validation in a subset of tissue cores from subjects with severe emphysema (see Additional file 1 for methods)
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