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Many people begin exploring peptide therapy when looking for ways to support growth hormone activity without turning to more aggressive options
Moreover, subsequent research should investigate the prospective contributions of these interventions beyond sarcopenia, particularly in the realms of preventing or alleviating age-related vascular aging, metabolic syndrome, and frailty
Given that the overall body of evidence in this review is predominantly of low-to-moderate quality and includes a proportion of non-significant findings, we recommend cautious clinical application, with stratified decision-making based on population characteristics and concomitant therapies, to avoid extrapolation beyond the evidentiary boundaries
All references FDA: Concerns with unapproved GLP-1 drugs used for weight loss NEJM (2023): Retatrutide Phase 2 trial in obesity Eli Lilly: Phase 2 retatrutide results published in NEJM Eli Lilly (Dec 2025): Phase 3 TRIUMPH-4 topline results announcement ClinicalTrials.gov: NCT05882045 (TRIUMPH-3) Drugs.com: Retatrutide status & timeline Lilly Trials: TRIUMPH-3 summary page
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