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Aquaculture 528:735538 Lu Q, Li H, Zou Y, Liu H, Yang L (2021) Astaxanthin as a microalgal metabolite for aquaculture: a review on the synthetic mechanisms, production techniques, and practical application

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Discontinuation rates range from 37% to 81% within the first year, driven by cost, side effects, and access barriers, with weight regain thereafter mediated through hormonal dysregulation, CNS maladaptation to reduced GLP-1 signaling, and -cell dysfunction