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Institute for Health Metrics and Evaluation, GBD Results, Accessed 24 November 2024
In an associated Commentary titled Thyroid Cancer Risk with GLP-1 Receptor Agonists: Evidence, Knowledge Gaps, and the Path Forward, Juan Brito, MD , from the Mayo Clinic, and coauthors, stated the following: this study stands out for its large scale and robust methodology
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FIGURE 2 FIGURE 3 FIGURE 4 Validation of selected metabolite biomarkers through selected reaction monitoring Figure 5 depicts the quantification results of acetylcarnitine selected as the final biomarker candidate in the validation set
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Hence, the action of dual GLP-1R/GcgR agonists likely results from a combination of central and peripheral mechanisms, at multiple target tissues
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