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& Perlman, S
Notably, no significant effect on total 24-hour energy expenditure was demonstrated , though a 4.6% increase was observed during the night period alone
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After four weeks at 2.5 mg, the dose increases to 5 mg per week
Pathological expansion and dysfunction of EAT promote AF through paracrine and vasocrine secretion of pro-inflammatory and pro-fibrotic cytokines, release of extracellular vesicles carrying arrhythmogenic cargo, direct infiltration, and modulation of local electrophysiology and autonomic signaling, thereby creating a substrate for atrial cardiomyopathy, fibrosis, electrical remodeling, and AF initiation/persistence
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