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FIGURE 4 Research on PD patients has shown abnormal expression of proteins involved in autophagy (Table 5) and Atg and ULK genes, which increased upstream regulators of autophagy and decreased downstream regulators, strengthening the link between the disease and this cellular mechanism (Miki et al., 2018)

Many Klinic patients in Boise experience appetite changes in the first week and visible weight loss by the fourth week

The increase of -H2AX adds to the hypothesis that HnB may be associated with DNA-damaging activity

Patients should be advised to report suspected side effects via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk or via the Yellow Card app)