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These findings highlight the peptides therapeutic potential for addressing male late-onset hypogonadism and age-related fertility decline
Mechanism involves NO system modulation (homeostatic regulationupregulating when deficient, moderating when excessive), VEGF/VEGFR2 upregulation for angiogenesis, FAK-paxillin pathway activation for cell migration (40% increase per Chang et al.), and EGR-1 transcription factor upregulation for growth factor sensitivity
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For M1 polarization, RAW264.7 cells were stimulated with LPS (100 ng mL 1 , Sigma-Aldrich, USA) and IFN- (20 ng mL 1 , ABclonal, China) for 24 h
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Nagai S, Ikeda K, Horie-Inoue K et al (2016) Estrogen modulates exercise endurance along with mitochondrial uncoupling protein 3 downregulation in skeletal muscle of female mice
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