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Using these enzyme preparations with a defined GSH concentration (20 M) in the established two-step in vitro reactions, we found that the extent of conversion of the ultrafiltered flavan-3,3,4-triol ( 4 ) depended on the applied concentration of the purified Pt GSTF8, confirming that this enzyme is required and sufficient for the observed conversion to cyanidin (Extended Data Fig

Interestingly, this specific isoform has been previously associated with worse breast cancer patient outcomes 26

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Moreover, the complexity of the cell composition of this tissue and the elevated oxygen levels corroborate to elevated capacity of the CNS in ROS production

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It's often taken by placing the recommended dosage under the tongue and holding it there for a brief period before swallowing to enhance absorption