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Defective p53 activity is increasingly implicated in the etiology of several additional uncommon genetic disorders, such as DiamondBlackfan anemia (DBA), CHARGE syndrome, and ATR-Seckel syndrome

13 , 655672, doi:10.1038/nrd4363 (2014)

Cuando el GSH es insuficiente, el organismo pierde eficiencia para eliminar estos compuestos reactivos, lo que favorece su acumulacin y genera una sobrecarga txica sistmica

Biomolecules & therapeutics, 33(1), 117128

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Mena MO, Moellmann VM, Bassetto CC, Lins JGG, Fernandes MA, Moreira GR, et al