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As of the time of writing, both agents remain in clinical development and have not received a marketing authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA)
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Defyne and Refyne are very similar, but Defyne is firmer and that means if you place it too close to the surface, youll be able to feel it, which is not ideal
The combination of high bioavailability, body-wide distribution, cGMP-verified quality from Instamed, and dramatically better real-world consistency makes sublingual the delivery method we recommend with confidence
A 10 mg vial covers roughly 23 weeks at that dose
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