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Alexiev BA, Chou PM, Jennings LJ

Effect of semaglutide treatment on a proteomic signature of CVD risk A 27-protein score has previously been described that predicts secondary CVD risk over 4 years, based on large multicohort data and using the same SomaScan technology used in our study 22 (Extended Data Table 1)

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However, rapid weight loss can also come with digestive changes, including reduced fiber intake, dehydration, and irregular bowel movementsall of which can contribute to the formation or worsening of hemorrhoids

Activated MC3R/MC4R are reported in the literature to couple to G s , stimulating adenylyl cyclase and elevating intracellular cAMP, which engages PKA-mediated downstream signalling