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This position alone can reduce straining by up to 50% according to research published in the Journal of Clinical Gastroenterology

PMID 9392310

This ensures safety and effectiveness

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Am J Emerg Med 28:798802 Zyoud SEH, Awang R, Sulaiman SAS (2012) Reliability of the reported ingested dose of acetaminophen for predicting the risk of toxicity in acetaminophen overdose patients

these patients tend to have a greater BP response to calcium-channel blockers and thiazide diuretics than to other antihypertensive drug classes (e.g., ACE inhibitors, angiotensin II receptor antagonists)