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Summary: Researchers unmasked a slight, statistically measurable increase in the risk of developing a rare, potentially permanent blinding condition known as ischemic optic neuropathy (a sudden restriction of blood flow to the optic nerve) among patients initiating GLP-1 therapy compared to standard diabetes regimens
Research indicates that insulin-resistant patients exhibit decreased mitochondrial oxidative capacity in skeletal muscle and downregulated BCAA catabolic enzyme expression, leading to accumulation of BCAAs and branched-chain acylcarnitines (114)
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In the liver, insulin promotes the conversion of glucose into glycogen for storage
Hydrate to help with side effects ideally with water or zero-calorie drinks Constipation and nausea are the most common side effects of GLP-1 use particularly when starting off on the drugs
Preclinical safety studies demonstrated no indication of pancreatitis or pancreatic inflammation in cynomolgus monkeys [29]
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