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Persistent joint pain past the first 2 weeks is commonly treated as a signal to reduce dose in community protocols
the doses were escalated every 4 weeks starting from 0.25 mg to 0.5 mg, 1.0 mg, and 1.7 mg until a dose of 2.4 mg was met and maintained for the remaining 16 weeks
SV shows a manageable and tolerable safety profile, with most common AEs being fatigue (51.6%), peripheral sensory neuropathy (48.4%), decreased appetite (35.5%), diarrhea (32.3%), dyspnea (32.3%), nausea (29%) and alopecia (29%)
Trimethylamine N-oxide (TMAO) is a metabolite produced when gut bacteria metabolize dietary compounds including levocarnitine and choline
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