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Clinical features include: Enlargement of the hands, feet, and jaw Paraesthesia in the extremities Amenorrhoea Coarse facial features, including a wide nose and rounded face Hypertension Cardiomegaly (enlargement of the heart) Treatment includes surgical removal of the pituitary tumour , typically via the sphenoid bone (transsphenoidal approach) if the tumour is large enough, or medical management using somatostatin analogues.
Chronobiological aspects of food intake and metabolism and their relevance on energy balance and weight regulation
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