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To explore this idea, we bred the MMTV-PyMT transgenic mouse strain (which spontaneously develops breast tumours) 26 with an uninduced Gclc f/f Rosa26 creERT2 mouse 27 in which the rate-limiting step in GSH synthesis, the glutamatecysteine ligase catalytic subunit (GCLC), can be knocked out throughout the body after induction with tamoxifen

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The Global Use of Medicines 2023 Outlook to 2027

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In ALS, lower levels of GSH were found in the motor cortex and the corticospinal tractus in patients compared to healthy controls 12,13,14,15

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