This single reaction sits at the intersection of two critical metabolic axes: The folate cycle axis: 5-MTHF is the methyl donor that MTR uses to regenerate methionine from homocysteine, simultaneously regenerating tetrahydrofolate (THF) that feeds back into one-carbon metabolism for nucleotide synthesis (thymidylate and purine biosynthesis)
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Luteolin can also increase ferroptosis by regulating TFEB, increasing TFEB expression and nuclear translocation and subsequent FTH1 lysosomal degradation in prostate cancer (Zheng et al., 2023)
Results - Fewer side effects (peeling, redness)
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Separate iron and antioxidant doses by at least four to six hours