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In one study of human intestinal cells, Akkermansia alone was shown to increase natural GLP-1 levels by over 2,000%
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This aligns with trial design: all major GLP-1 trials, including STEP-1 and SURMOUNT-1, required participants to follow a 500-calorie daily deficit and at least 150 minutes per week of moderate physical activity
Common adverse reactions observed in adolescents include headache, abdominal pain, nausea, vomiting, and diarrhea, mirroring those reported in adult populations ( 10 , 11 )
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