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Wanner C, Lachin JM, Inzucchi SE, Fitchett D, Mattheus M, George J, Woerle HJ, Broedl UC, von Eynatten M, Zinman B, EMPA-REG OUTCOME Investigators

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Modified GRF 1-29: Somatotroph Biology in GHRH Knock-Out Models A preclinical investigation [8] in GHRH knock-out (GHRHKO) mice examined whether once-daily exposure to CJC-1295, structurally representative of the Modified GRF 1-29 class, might normalize overall composition and GH-axis parameters in animals lacking endogenous GHRH signaling

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Determination of total concentration of chemically labeled metabolites as a means of metabolome sample normalization and sample loading optimization in mass spectrometry-based metabolomics