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Functional effect of adeno-associated virus mediated gene transfer of aromatic L-amino acid decarboxylase into the striatum of 6-OHDA-lesioned rats

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GLP-1 was subsequently identified as a physiological inhibitor of appetite and food intake, and based on these actions, the GLP-1 receptor agonists are today considered among the most powerful and effective antiobesity and antidiabetic agents available, with the added benefits of reducing the risk of the cardiovascular and renal complications associated with these conditions

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Diabetes-induced ER stress activates pro-apoptotic pathways involving C/EBP homologous protein (CHOP), c-Jun N-terminal kinase (JNK), and caspase-12, leading to germ cell apoptosis and impaired spermatogenesis [127, 128]