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The SELECT trial, which included patients with CV disease and overweight or obesity (many also had increased risk for diabetes), showed a reduction in major adverse CV events (defined as CV death, nonfatal heart attack, and nonfatal stroke) of 20% with weekly subcutaneous semaglutide 2.4 mg

These are pharmacological observations from published research

In addition to appetite suppression and increased satiety, semaglutide GLP-1 offers other benefits

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doi:10.1152/ajpendo.00054.2024.