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When severe, it can make toes and lower feet feel intensely cold and may be associated with color changes, pale, then blue, then red as circulation returns
SD: Formal analysis, Writing review & editing
The mechanism operates at multiple levels: lower insulin reduces ovarian androgen synthesis, while weight loss from semaglutide further decreases circulating androgens stored in adipose tissue
ADA Standards of Care in Diabetes
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Li HY, Zhou DD, Gan RY, Huang SY, Zhao CN, Shang A, et al
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