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Comparing Receptor Selectivity, Half-Life, and Feedback Regulation The bottom line: IGF-1 LR3 delivers predictable, systemic anabolism in models where pituitary function is impaired or irrelevant to the research question

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Probe concentration was initially optimized for binding saturation, with 2 M selected in line with ABPP published protocol 70 , and inhibitor doseresponse confirmed near-saturating competition and robust target detection (Supplementary Fig