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The sample sizes for both in vitro transfection studies (Hepa1-6 and HepG2 cells) and in vivo studies (Balb/c and DIO mice) were predetermined
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Commonly reported side effects included: Nausea (the most frequently reported, particularly at higher doses) Vomiting Diarrhoea Decreased appetite Constipation Eructation (belching) At the 12 mg dose, gastrointestinal adverse events were reported in a higher proportion of participants compared with lower doses, though most did not lead to treatment discontinuation
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